Ligand (T3) dependent and independent effects of thyroid hormone receptors upon human TRH gene transcription in neuroblastoma cells.

@article{Feng1994LigandD,
  title={Ligand (T3) dependent and independent effects of thyroid hormone receptors upon human TRH gene transcription in neuroblastoma cells.},
  author={Pingfu Feng and Q L Li and Teturou Satoh and John F. Wilber},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={200 1},
  pages={171-7}
}
Thyrotropin releasing hormone (TRH) gene is regulated negatively at the transcriptional level by thyroid hormone (T3) in rat anterior hypothalamus. The actions of T3 upon other target genes are known to be mediated through the thyroid hormone receptors (TR), TR alpha and TR beta. To explore whether the inhibitory regulation of human (h) TRH gene transcription by T3 is TR isoform specific and whether TRH gene transcription can be modulated as well by unliganded TR isoforms, transient gene… CONTINUE READING

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