Ligand–Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules

@inproceedings{Haburcak2016LigandReceptorIM,
  title={Ligand–Receptor
Interaction Modulates the Energy
Landscape of Enzyme-Instructed Self-Assembly of Small Molecules},
  author={Richard Haburcak and Junfeng Shi and Xuewen Du and Dan Yuan and Bing Xu},
  booktitle={Journal of the American Chemical Society},
  year={2016}
}
The concurrence of enzymatic reaction and ligand-receptor interactions is common for proteins, but rare for small molecules and has yet to be explored. Here we show that ligand-receptor interaction modulates the morphology of molecular assemblies formed by enzyme-instructed assembly of small molecules. While the absence of ligand-receptor interaction allows… CONTINUE READING