Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor

@article{Ward2009LigandinducedAO,
  title={Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor},
  author={Colin W. Ward and Michael C. Lawrence},
  journal={BioEssays},
  year={2009},
  volume={31}
}
Current models of insulin binding to the insulin receptor (IR) propose (i) that there are two binding sites on the surface of insulin which engage with two binding sites on the receptor and (ii) that ligand binding involves structural changes in both the ligand and the receptor. Many of the features of insulin binding to its receptor, namely B‐chain helix interactions with the leucine‐rich repeat domain and A‐chain residue interactions with peptide loops from another part of the receptor, are… 

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