Ligament and tendon repair through regeneration using mesenchymal stem cells.

@article{Ramdass2015LigamentAT,
  title={Ligament and tendon repair through regeneration using mesenchymal stem cells.},
  author={Bharathi Ramdass and Prasad S. Koka},
  journal={Current stem cell research \& therapy},
  year={2015},
  volume={10 1},
  pages={
          84-8
        }
}
  • B. Ramdass, P. Koka
  • Published 31 December 2014
  • Biology
  • Current stem cell research & therapy
One of Nature's gifts to mankind is mesenchymal stem cells (MSC's). They are multipotent in nature and are present literally in every tissue. Since, they possess certain characteristics of stem cells such as self-renewal and differentiation they are known to be one of the key players in normal tissue homeostasis. This novel function of mesenchymal stem cells has been explored by scientists in the field of regenerative medicine. This review gives an insight of the various sources of mesenchymal… 
View on PubMed
bayoaksphysicalmed.com
14 Citations
Highly Influential Citations
1
Background Citations
6

14 Citations

Citation Type

Citation Type

Cell therapies for tendons and ligament repair
Stem Cells and Tendon Regeneration
TLDR
Many studies have proven that stem cells can prevent inflammatory reactions and in turn prevent adhesions after healing of the tendon, and with the help of scaffolds and growth factors they can regenerate the tendon.
Dielectrophoretic Characterization of Tenogenically Differentiating Mesenchymal Stem Cells
TLDR
Differences in dielectric properties with tenogenesis indicate that the DEP-based label-free separation of tenogenically differentiating cells is possible and avoids the complications of current label-dependent flow cytometry-based separation techniques.
The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation
TLDR
It is demonstrated scleraxis, a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of MSC towards tenocyte differentiation, and mechanical loading-mediated tenocytic differentiation follows a similar pathway.
Mechanical Actuation Systems for the Phenotype Commitment of Stem Cell-Based Tendon and Ligament Tissue Substitutes
TLDR
All physical parameters must be adapted to the specific response of the cells used and the tensile properties of the scaffold, especially when uniaxial cyclic forces are applied to cells engineered into natural or decellularized scaffolds.
Bone marrow mesenchymal stem cells co-culture and in vivo transplantation inhibit degeneration of intervertebral disc in rabbits
TLDR
The transplantation of cocultured cells may inhibit the progression of IDD in rabbit models and 50:50 co-culture of notochord cells and MSCs causes strongest cell proliferation ability.
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies
TLDR
The studies in this review showcased the safety and efficacy of MSC-EV therapy for tendon/ligament healing, by attenuating the initial inflammatory response and accelerating tendon matrix regeneration, providing a basis for potential clinical use in tendon-ligament repair.
Injectable hydrogels for tendon and ligament tissue engineering
TLDR
In future T/L applications, it is necessary develop an injectable hydrogel with mechanics, tissue damage‐specific binding, and disease response, and prospects for injectable and biodegradablehydrogels for its treatment are presented.
Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)
TLDR
Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.
Does an Injection of Adipose-Derived Mesenchymal Stem Cells Loaded in Fibrin Glue Influence Rotator Cuff Repair Outcomes? A Clinical and Magnetic Resonance Imaging Study
TLDR
Although still in the early stages of application, MSC augmentation of surgical rotator cuff repair appears useful for providing an adequate biological environment around the repair site.
...
1
2
...

References

SHOWING 1-10 OF 71 REFERENCES
Adult mesenchymal stem cells and cell-based tissue engineering
The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects…
Mesenchymal stem cells in tissue repairing and regeneration: Progress and future
TLDR
This review summarizes the important studies that have investigated the use of MSCs as a therapeutic agent for regenerative medicine, immune disorders, cancer, and gene therapy and discusses the mechanisms involved in MSC-based therapies and clinical-grade MSC manufacturing.
How mesenchymal stem cells interact with tissue immune responses.
Adult mesenchymal stem cells and their potency in the cell-based therapy.
TLDR
This review mainly throws light on the biology of MSCs, including their efficiency in treating several diseases and also the progress of the use of iPSC-derived MSC widely in the clinic.
Application of stem cells derived from the periodontal ligament or gingival tissue sources for tendon tissue regeneration.
Mesenchymal Stem Cells in Bone Regeneration.
TLDR
While animal models have demonstrated efficacy in the delivery of MSCs to promote healing, more research is needed to understand ideal donor cells, cultivation methods, and delivery before stem cell therapy approaches can be utilized to repair bone.
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
  • A. Caplan
  • Biology, Medicine
    Journal of cellular physiology
  • 2007
TLDR
The biological basis for the in vivo functioning of MSCs through development and aging is summarized and they appear to be valuable mediators for tissue repair and regeneration.
Immunobiology of mesenchymal stem cells
TLDR
This review focuses on the crosstalk between MSCs and immune responses and their potential clinical applications, especially in inflammatory diseases.
Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: a clinical report.
Exploring the application of stem cells in tendon repair and regeneration.
...
1
2
3
4
5
...