Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up.

@article{Allan2015LifetimeHA,
  title={Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up.},
  author={Charlotte Allan and Enikő Zsoldos and Nicola Filippini and Claire E. Sexton and Anya Topiwala and Vyara Valkanova and Archana Singh-Manoux and Adam G Tab{\'a}k and Martin J. Shipley and Clare Mackay and Klaus P. Ebmeier and Mika Kivim{\"a}ki},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2015},
  volume={206 4},
  pages={
          308-15
        }
}
BACKGROUND Hypertension is associated with an increased risk of dementia and depression with uncertain longitudinal associations with brain structure. AIMS To examine lifetime blood pressure as a predictor of brain structure in old age. METHOD A total of 190 participants (mean age 69.3 years) from the Whitehall II study were screened for hypertension six times (1985-2013). In 2012-2013, participants had a 3T-magnetic resonance imaging (MRI) brain scan. Data from the MRI were analysed using… CONTINUE READING

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