Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project.

@article{Lovallo2012LifetimeAL,
  title={Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project.},
  author={William R. Lovallo and Noha H Farag and Kristen H. Sorocco and Andrew J. Cohoon and Andrea S. Vincent},
  journal={Biological psychiatry},
  year={2012},
  volume={71 4},
  pages={344-9}
}
BACKGROUND Can stressful events in early life alter the response characteristics of the human stress axis? Individual differences in stress reactivity are considered potentially important in long-term health and disease; however, little is known about the sources of these individual differences. We present evidence that adverse experience in childhood and adolescence can alter core components of the stress axis, including cortisol and heart rate reactivity. METHODS We exposed 354 healthy… CONTINUE READING