Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

@article{Nunn2009LifestyleinducedMI,
  title={Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?},
  author={Alistair V W Nunn and Jimmy D. Bell and Geoffrey W. Guy},
  journal={Nutrition & Metabolism},
  year={2009},
  volume={6},
  pages={16 - 16}
}
The metabolic syndrome may have its origins in thriftiness, insulin resistance and one of the most ancient of all signalling systems, redox. Thriftiness results from an evolutionarily-driven propensity to minimise energy expenditure. This has to be balanced with the need to resist the oxidative stress from cellular signalling and pathogen resistance, giving rise to something we call 'redox-thriftiness'. This is based on the notion that mitochondria may be able to both amplify membrane-derived… CONTINUE READING