Lifestyle factors and colorectal cancer risk (2): a systematic review and meta‐analysis of associations with leisure‐time physical activity

  title={Lifestyle factors and colorectal cancer risk (2): a systematic review and meta‐analysis of associations with leisure‐time physical activity},
  author={David J Harriss and Greg Atkinson and Alan M Batterham and Keith P George and N. Tim Cable and Thomas Reilly and Najib Haboubi and Andrew G. Renehan},
  journal={Colorectal Disease},
Objective Increased physical activity may decrease the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we performed a systematic review and meta‐analysis of prospective observational studies to quantify gender‐specific risk associated with increased leisure‐time physical activity (LT‐PA). 

Impact of Diet and Exercise on Colorectal Cancer.

Recent advances in the link between physical activity, sedentary behavior, physical fitness, and colorectal cancer

Physical inactivity, defined as time spent sitting, increases CRC risk independent of PA and may require novel interventions distinct from those targeting PA, and cardiorespiratory fitness is inversely associated with CRC risk and mortality and may provide a potential tool for risk stratification and intervention.

The association between physical activity and renal cancer: systematic review and meta-analysis

A comprehensive meta-analysis provides strong support for an inverse relation of physical activity to renal cancer risk, and future high-quality studies are required to discern which specific types, intensities, frequencies, and durations ofPhysical activity are needed for renalcancer risk reduction.

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles and prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention.

Combined Effect of Healthy Lifestyle Factors and Risks of Colorectal Adenoma, Colorectal Cancer, and Colorectal Cancer Mortality: Systematic Review and Meta-Analysis

Adoption of a higher number of healthy lifestyles is associated with lower risk of CRC, CRA, and CRC-specific mortality, and promoting healthy lifestyle could reduce the burden of CRC.

Physical Activity and Cancer

Public health recommendations for appropriate changes in activity levels are needed; unfortunately, at this time, there is no exact physical activity prescription to give to the public.

Effects of Physical Activity on Risk of Colorectal Cancer: A Case–control Study

The study suggests that the risk of CRC will decrease in individuals with higher leisure physical activities (especially with an increase in hours of brisk walking during the day) and in women with a past history of cancer or any physical disability.

Lifestyle in the Prevention and Management of Cancer: Physical Activity

There is some evidence, however, that physical activity may be protective of the more aggressive forms of the disease, and further research is needed to better quantify the specific components of physical activity required to reduce the risk for different cancers.

Physical Activity and Gastric Cancer Risk: A Systematic Review and Meta-Analysis

This meta-analysis suggests a protective effect of physical activity regarding gastric cancer risk, especially in Asian populations.



Lifestyle factors and colorectal cancer risk (1): systematic review and meta‐analysis of associations with body mass index

A systematic review and meta‐analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub‐site and study characteristics.

A meta‐analysis of the association of physical activity with reduced risk of colorectal cancer

This paper reviews the available evidence for a link between exercise and large bowel cancer and concludes that physical activity may be associated with reduced risk of colorectal cancer.

Mechanisms linking physical activity with cancer

Randomized clinical trials have shown that physical activity interventions can change biomarkers of cancer risk, and Observational studies can also provide useful information on mechanisms that might link physical activity to cancer.

Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study

It is suggested that physical activity may prevent colorectal cancer among Japanese men, and this inverse association was essentially limited to colon cancer.

Sedentary jobs and colon cancer.

Food habits and physical activity during leisure time were examined in the same occupations in another sample and it was judged unlikely that confounding from these factors could explain the association between physical job activity and colon cancer.

Physical activity and incidence of cancer in diverse populations: a preliminary report.

Comparing and contrasts four studies on exercise and cancer in relation to levels of physical activity on the job and in leisure time is compared and contrasts.

Physical Activity and Risk of Colon and Rectal Cancers: The European Prospective Investigation into Cancer and Nutrition

It is found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.

Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers.

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Evidence is provided for a protective role of physical activity in colon and rectal cancer among male smokers and among those most active in both work and leisure.

Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis

The positive association between diabetes, blood glucose, and colorectal cancer in women, at least in part, support the hypothesis that insulin may act as a tumour promoter in coloreCTal carcinogenesis, and the inverse association with leisure-time physical activity in men is found to be negative.

Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study.

M Males and females who had 3 or more children showed a significantly reduced risk of colorectal cancer, but those with no children did not show the highest risk and there was no association with either vitamin C from supplements or with total vitamin C intake.