Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol.

@article{Marchand1997LifestyleAN,
  title={Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol.},
  author={Lo{\"i}c Le Marchand and Adrian A. Franke and Laurie J Custer and Lynne Ross Wilkens and Robert V. Cooney},
  journal={Pharmacogenetics},
  year={1997},
  volume={7 1},
  pages={11-9}
}
Cytochrome CYP1A2, a liver enzyme responsible for the metabolic activation of a number of putative human carcinogens, exhibits wide inter-individual differences in activity. In order to characterize sources of variability in CYP1A2 activity, we phenotyped (with the caffeine test) 90 subjects of various ethnic backgrounds in Hawaii. Forty-three subjects were patients with in-situ colorectal cancer treated by polypectomy and 47 were healthy population controls. Subjects were also administered a… CONTINUE READING

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