Lifespan of neurons is uncoupled from organismal lifespan.

  title={Lifespan of neurons is uncoupled from organismal lifespan.},
  author={Lorenzo Magrassi and Ketty Leto and Ferdinando Dott. Rossi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 11},
Neurons in mammals do not undergo replicative aging, and, in absence of pathologic conditions, their lifespan is limited only by the maximum lifespan of the organism. Whether neuronal lifespan is determined by the strain-specific lifetime or can be extended beyond this limit is unknown. Here, we transplanted embryonic mouse cerebellar precursors into the developing brain of the longer-living Wistar rats. The donor cells integrated into the rat cerebellum developing into mature neurons while… CONTINUE READING

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