Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.

@article{MirandaVizuete2006LifespanDI,
  title={Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.},
  author={Antonio Miranda-Vizuete and Juan Carlos Fierro Gonz{\'a}lez and Gabriele Gahmon and Jan A Burghoorn and Pl{\'a}cido Navas and Peter Swoboda},
  journal={FEBS letters},
  year={2006},
  volume={580 2},
  pages={
          484-90
        }
}
Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that is expressed in ASJ ciliated sensory neurons, and to some extent also in the posterior-most intestinal cells. TRX-1 is active at reducing protein disulfides in the presence of a… CONTINUE READING
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