Lifespan and oxidative stress show a non-linear response to atmospheric oxygen in Drosophila.

@article{Rascn2010LifespanAO,
  title={Lifespan and oxidative stress show a non-linear response to atmospheric oxygen in Drosophila.},
  author={Brenda Rasc{\'o}n and Jon Fewell Harrison},
  journal={The Journal of experimental biology},
  year={2010},
  volume={213 Pt 20},
  pages={3441-8}
}
Oxygen provides the substrate for most ATP production, but also serves as a source of reactive oxygen species (ROS), which can induce cumulative macromolecular oxidative damage and cause aging. Pure oxygen atmospheres (100 kPa) are known to strongly reduce invertebrate lifespan and induce aging-related physiological changes. However, the nature of the relationship between atmospheric oxygen, oxidative stress, and lifespan across a range of oxygen levels is poorly known. Developmental responses… CONTINUE READING

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