Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes

  title={Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes},
  author={Mikhail Shaposhnikov and Ekaterina Proshkina and Lyubov Shilova and Alex Zhavoronkov and Alexey А. Moskalev},
  booktitle={Scientific reports},
DNA repair declines with age and correlates with longevity in many animal species. In this study, we investigated the effects of GAL4-induced overexpression of genes implicated in DNA repair on lifespan and resistance to stress factors in Drosophila melanogaster. Stress factors included hyperthermia, oxidative stress, and starvation. Overexpression was either constitutive or conditional and either ubiquitous or tissue-specific (nervous system). Overexpressed genes included those involved in… CONTINUE READING
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Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

  • MacRae, L S.
  • Aging Cell, doi: 10.1111/acel.12314
  • 2015

Insights into the evolution of longevity from the bowhead whale genome

  • M Keane
  • Cell Rep
  • 2015

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