Life without the iodothyronine deiodinases.

@article{Galton2014LifeWT,
  title={Life without the iodothyronine deiodinases.},
  author={Valerie Anne Galton and Ellis A C de Waard and Albert F. Parlow and Donald L. St. Germain and Arturo Hernandez},
  journal={Endocrinology},
  year={2014},
  volume={155 10},
  pages={4081-7}
}
The three iodothyronine deiodinases (D1, D2, and D3) play major roles in determining the tissue and cellular content of the active thyroid hormone, T3. The D1 and D2 5'-deiodinate T4 to T3 and the D3 5-deiodinates T4 and T3 to inactive forms. 5'-Deiodinase-deficient mice (D1/D2KO) have a mild gross phenotype, whereas D3-deficient mice (D3KO) exhibit significant phenotypic abnormalities of the hypothalamic/pituitary/thyroid axis and other organ systems and are not viable in some background… CONTINUE READING