Life without tRNAIle-lysidine synthetase: translation of the isoleucine codon AUA in Bacillus subtilis lacking the canonical tRNA2Ile

@inproceedings{Khrer2014LifeWT,
  title={Life without tRNAIle-lysidine synthetase: translation of the isoleucine codon AUA in Bacillus subtilis lacking the canonical tRNA2Ile},
  author={Caroline K{\"o}hrer and Debabrata Mandal and Kirk W. Gaston and Henri Grosjean and Patrick A. Limbach and Uttam L. RajBhandary},
  booktitle={Nucleic acids research},
  year={2014}
}
Translation of the isoleucine codon AUA in most prokaryotes requires a modified C (lysidine or agmatidine) at the wobble position of tRNA2(Ile) to base pair specifically with the A of the AUA codon but not with the G of AUG. Recently, a Bacillus subtilis strain was isolated in which the essential gene encoding tRNA(Ile)-lysidine synthetase was deleted for the first time. In such a strain, C34 at the wobble position of tRNA2(Ile) is expected to remain unmodified and cells depend on a mutant… CONTINUE READING
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