Life without dihydrofolate reductase FolA.

  title={Life without dihydrofolate reductase FolA.},
  author={Hannu Myllykallio and Damien Leduc and Jonathan Fil{\'e}e and Ursula Liebl},
  journal={Trends in microbiology},
  volume={11 5},
Reduced folate derivatives participate in numerous reactions of bacterial intermediary metabolism. Consequently, the well-characterized enzyme implicated in the formation of tetrahydrofolate--dihydrofolate reductase FolA--was considered to be essential for bacterial growth. However, comparative genomics has revealed several bacterial genome sequences that appear to lack the folA gene. Here, we provide in silico evidence indicating that folA-lacking bacteria use a recently discovered class of… CONTINUE READING

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