Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.

@article{Nedergaard2001LifeWU,
  title={Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice.},
  author={Jan Nedergaard and Valeria Golozoubova and Anita Matthias and Irina M. Shabalina and Kenji Ohba and Kerstin B E Ohlson and Anders Jacobsson and Barbara A Cannon},
  journal={Biochemical Society transactions},
  year={2001},
  volume={29 Pt 6},
  pages={
          756-63
        }
}
Mice devoid of the original uncoupling protein UCP1 have provided opportunities to delineate UCP1 function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis. However, they only show a 2-fold decrease in sensitivity to the de-energizing effect of free fatty acids, compared with UCP1-containing mitochondria, whereas they possess a (UCP1… CONTINUE READING
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