Life with or without AIF.

  title={Life with or without AIF.},
  author={Emilie Hangen and Klas Blomgren and Paule B{\'e}nit and Guido Kroemer and Nazanine Modjtahedi},
  journal={Trends in biochemical sciences},
  volume={35 5},
Apoptosis-inducing factor (AIF) was initially discovered as a caspase-independent death effector. AIF fulfills its lethal function after its release from mitochondria and its translocation to the nucleus of the dying cell. The contribution of AIF to programmed cell death is dependent upon the cell type and apoptotic insult. Recent in vivo data indicate that, in addition to its lethal activity, AIF plays a vital mitochondrial role in healthy cells. A segment of AIF which is dispensable for its… CONTINUE READING

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AIF: not just an apoptosis-inducing factor.

Annals of the New York Academy of Sciences • 2009

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