Life with Carbon Monoxide

@article{Ragsdale2004LifeWC,
  title={Life with Carbon Monoxide},
  author={S. Ragsdale},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  year={2004},
  volume={39},
  pages={165 - 195}
}
  • S. Ragsdale
  • Published 2004
  • Chemistry, Medicine
  • Critical Reviews in Biochemistry and Molecular Biology
This review focuses on how microbes live on CO as a sole source of carbon and energy and with CO by generating carbon monoxide as a metabolic intermediate. The use of CO is a property of organisms that use the Wood-L jungdahl pathway of autotrophic growth. The review discusses when CO metabolism originated, when and how it was discovered, and what properties of CO are ideal for microbial growth. How CO sensing by a heme-containing transcriptional regulatory protein activates the expression of… Expand
Metal centers in the anaerobic microbial metabolism of CO and CO2.
TLDR
Studies of CO and CO(2) enzymology are of practical significance, and offer fundamental insights into important biochemical reactions involving metallocenters that act as nucleophiles to form organometallic intermediates and catalyze C-C and C-S bond formations. Expand
Life on the fringe: microbial adaptation to growth on carbon monoxide
TLDR
It appears that carboxydotrophs are adapted to provide a metabolic “currency exchange” system in microbial communities in which CO arising either abiotically or biogenically is converted to CO 2 and H 2 that feed major metabolic pathways for energy conservation or carbon fixation. Expand
Cyanide and Carbon Monoxide Ligand Formation in Hydrogenase Biosynthesis
Carbon monoxide (CO) and cyanide (CN–) can act as potent inhibitors of enzymes necessary for primary biochemical processes, however they also play important roles in biological systems. Well-studiedExpand
The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris.
TLDR
As expected, CooS(C) is Ni-loaded, reversibly converts CO and CO₂, displays the typical Cred1 and Cred2 EPR signatures of the C-cluster and activates in the presence of methyl viologen and CO in an autocatalytic process, however, Ni- loaded CooC reaches maximum activity only upon reductive treatment in the Presence of exogenous nickel, a phenomenon that had not been observed before. Expand
Carbon monoxide-dependent energy metabolism in anaerobic bacteria and archaea
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Recent insights into the CO-dependent physiology of anaerobic microorganisms with a focus on methanogenic archaea are summarized and Methanosarcina acetivorans, thought to strictly rely on the process of methanogenesis, exemplifies how the beneficial redox properties of CO can be exploited in unexpected ways by anaerobia microorganisms. Expand
Something special about CO‐dependent CO 2 fixation
TLDR
It appears that no alternative mechanisms to the CO‐dependent reaction of ACS have evolved in nearly 4 billion years, indicating an ancient and mechanistically essential role for CO at the onset of metabolism. Expand
Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901
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Analysis of the genome of the thermophilic bacterium Carboxydothermus hydrogenoformans reveals the presence of at least five highly differentiated anaerobic carbon monoxide dehydrogenase complexes, which may in part explain how this species is able to grow so much more rapidly on CO than many other species. Expand
Enzymology of the Wood–Ljungdahl Pathway of Acetogenesis
  • S. Ragsdale
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2008
The biochemistry of acetogenesis is reviewed. The microbes that catalyze the reactions that are central to acetogenesis are described and the focus is on the enzymology of the process. These microbesExpand
Microbial CO Conversions with Applications in Synthesis Gas Purification and Bio-Desulfurization
TLDR
CO utilization by various anaerobic micro-organisms and their possible role in biotechnological processes, with a focus on hydrogen production and bio-desulfurization are reviewed. Expand
Older Than Genes: The Acetyl CoA Pathway and Origins
  • W. Martin
  • Chemistry, Medicine
  • Frontiers in Microbiology
  • 2020
TLDR
The antiquity of the acetyl CoA pathway is usually seen in light of CO2 fixation; its role in primordial energy coupling via acyl phosphates and substrate-level phosphorylation is emphasized here. Expand
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