Life with CO or CO2 and H2 as a source of carbon and energy

@article{Wood1991LifeWC,
  title={Life with CO or CO2 and H2 as a source of carbon and energy},
  author={H G Wood},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={156 - 163}
}
  • H. Wood
  • Published 1 February 1991
  • Chemistry, Medicine
  • The FASEB Journal
An account is presented of the recent discovery of a pathway of growth by bacteria in which CO or CO2 and H2 are sources of carbon and energy. The Calvin cycle and subsequently other cycles were discovered in the 1950s, and in each the initial reaction of CO2 involved adding CO2 to an organic compound formed during the cyclic pathway (for example, CO2 and ribulose diphosphate). Studies were initiated in the 1950s with the thermophylic anaerobic organism Clostridium thermoaccticum, which Barker… Expand
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References

SHOWING 1-10 OF 61 REFERENCES
CO2 fixation in acetogenic bacteria: Variations on a theme
TLDR
Emphasis is placed upon the acetyl CoA pathway in acetogenic bacteria, but important advances in the study of other strict anaerobes are also considered. Expand
The autotrophic pathway of acetogenic bacteria. Role of CO dehydrogenase disulfide reductase.
An enzyme from Clostridium thermoaceticum has been isolated which reduces disulfides of carbon monoxide dehydrogenase and it has been named CO dehydrogenase disulfide reductase. The enzyme is aExpand
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
TLDR
These studies support the view that CO dehydrogenase is the condensing enzyme that forms acetyl-CoA from its component parts, and a scheme is presented to account for the role of CO dehydrogensase in the exchange reaction and in the synthesis of acetate. Expand
Acetyl-CoA pathway of autotrophic growth. Identification of the methyl-binding site of the CO dehydrogenase.
TLDR
Results demonstrate that a cysteine of the beta subunit is the methyl acceptor and that CO dehydrogenase per se catalyzes the synthesis of acetyl-CoA. Expand
Controlled potential enzymology of methyl transfer reactions involved in acetyl-CoA synthesis by CO dehydrogenase and the corrinoid/iron-sulfur protein from Clostridium thermoaceticum.
Many anaerobic bacteria fix CO2 via the Wood pathway of acetyl-CoA synthesis. Carbon monoxide dehydrogenase (CODH), also called acetyl-CoA synthase, accepts the methyl group from the methylatedExpand
Synthesis of Acetyl Coenzyme A from Carbon Monoxide, Methyltetrahydrofolate, and Coenzyme A by Enzymes from Clostridium thermoaceticum
TLDR
It is proposed that these reactions are part of the mechanism which enables certain autotrophic bacteria to grow on CO and that CH3THF is synthesized from CO and tetrahydrofolate which then is converted to acetyl-CoA, which serves as a precursor in other anabolic reactions. Expand
Chemical modification of the functional arginine residues of carbon monoxide dehydrogenase from Clostridium thermoaceticum.
TLDR
The role of arginine residues in binding of CoA by CODH is determined and evidence is presented that the arginines interact with the pyrophosphate moiety of Coa. Expand
Evidence that an iron-nickel-carbon complex is formed by reaction of CO with the CO dehydrogenase from Clostridium thermoaceticum.
TLDR
It is demonstrated that iron is also a component of this ESR-detectable complex, and it is proposed that these atoms exist in a spin-coupled complex with net spin = 1/2, analogous to other iron-sulfur centers in which the metals are bridged by acid-labile sulfide. Expand
Involvement of tryptophan residues at the coenzyme A binding site of carbon monoxide dehydrogenase from Clostridium thermoaceticum.
TLDR
It appears that certain tryptophans are involved at or near the CoA binding site of CODH, which plays a central role in the newly discovered acetyl-CoA pathway. Expand
Purification of carbon monoxide dehydrogenase, a nickel enzyme from Clostridium thermocaceticum.
TLDR
It has been determined that the dehydrogenase is a metallo nickel enzyme and that ferredoxin and a membrane-bound b-type cytochrome, both obtained from C. thermoaceticum, are rapidly reduced by the enzyme in the presence of carbon monoxide and both are considered to be native electron carriers. Expand
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