Life with 6000 Genes

@article{Goffeau1996LifeW6,
  title={Life with 6000 Genes},
  author={Andr{\'e} Goffeau and Bart Barrell and Howard Bussey and R W Davis and Bernard Dujon and Horst Feldmann and Francis Galibert and J{\"o}rg D. Hoheisel and Claude Jacq and Mark Johnston and Edward J Louis and Hans-Werner Mewes and Yoko Murakami and Peter Philippsen and Herv{\'e} Tettelin and Stephen G. Oliver},
  journal={Science},
  year={1996},
  volume={274},
  pages={546 - 567}
}
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome… 
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4,044 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
160
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4,044 Citations

Exploiting the complete yeast genome sequence.
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The 4,639,221-base pair sequence of Escherichia coli K-12 is presented and reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident.
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This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.
The Reference Genome Sequence of Saccharomyces cerevisiae: Then and Now
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The genome of the budding yeast Saccharomyces cerevisiae, the first completely sequenced from a eukaryote, was updated recently in its first major update since 1996 and serves as the anchor for further innovations in yeast genomic science.
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Genomic sequencing is now being extended to the pathogenic yeast, Candida albicans, a hemiascomycete which can grow in unicellular form as well as filamentous form, and Cryptococcus neoformans, a basidiomycete.
Large-scale mutagenesis: yeast genetics in the genome era.
Parallel identification of new genes in Saccharomyces cerevisiae.
TLDR
Through combined evidence, a combination of expression profiling and mass spectrometry is used to verify the independent transcription of 138 and the translation of 50 previously nonannotated genes in the Saccharomyces cerevisiae genome.
Complete transcriptional map of yeast chromosome XI in different life conditions.
TLDR
It is shown that transcript levels and regulation patterns are not statistically different between ORFs of unknown function, which constitute ca.
What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.
TLDR
The German neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively, providing a first overview of the protein equipment of a filamentous fungus.
Genome and protein evolution in eukaryotes.
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References

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TLDR
The analysis of this chromosome confirmed general chromosome patterns but also revealed particular novel features of chromosomal organization, including several that are related to genes that perform differentiated functions in multicellular organisms of are involved in malignancy.
The complete genome sequence of Escherichia coli K-12.
TLDR
The 4,639,221-base pair sequence of Escherichia coli K-12 is presented and reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident.
The complete DNA sequence of yeast chromosome III
The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The…
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TLDR
The complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII reveals that it contains 269 predicted or known genes (300 base pairs or larger); of the 210 novel genes, 65 are predicted to encode proteins that are similar to other proteins of known or predicted function.
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TLDR
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TLDR
The complete nucleotide sequence of Saccharomyces cerevisiae chromosome VI has revealed that it contains 129 predicted or known genes, thirty-seven of which have been identified previously, and 39 of which are highly homologous to previously identified genes.
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TLDR
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  • B. Dujon
  • Biology
    Trends in genetics : TIG
  • 1996
Pseudogenes in yeast?
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