Life-threatening cardiac manifestations of primary antiphospholipid syndrome


We report a rare case of primary antiphospholipid syndrome (APS) in a 43-year-old man presenting as recurrent acute coronary stent thrombosis and complicated by three myocardial infarctions. As illustrated in this report, in APS patients recurrent life-threatening arterial thrombotic events may occur in spite of recommended anticoagulant therapy. We conclude that the APS should be considered as a potential cause of acute coronary syndrome, particularly in young individuals with a history of recurrent thrombotic events and/or with abnormal coagulation test results. Further studies are needed to determine the best therapeutic strategy for APS patients with acute coronary syndrome.

DOI: 10.1007/s00380-009-1193-7


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@article{Grzybczak2009LifethreateningCM, title={Life-threatening cardiac manifestations of primary antiphospholipid syndrome}, author={Rafal Grzybczak and Anetta Undas and Pawel Rostoff and Andrzej Gackowski and Urszula Czubek and Katarzyna Stopyra and Wieslawa Piwowarska}, journal={Heart and Vessels}, year={2009}, volume={25}, pages={267-269} }