Life threatening and occult mediastinal haemorrhage secondary to acquired factor VIII deficiency.


Dear Editor, Acquired Factor VIII (FVIII) deficiency is a rare disorder occurring at a rate of approximately 1 person per million each year.1 It is due to the spontaneous development of auto-antibodies against FVIII. In 50% of the cases, no cause is identified, although it can be associated with pregnancy, autoimmune disease and malignancy.1 Inhibition of… (More)


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