Life-threatening Pyridium Plus intoxication: a case report.

  title={Life-threatening Pyridium Plus intoxication: a case report.},
  author={T L Truman and Joseph J. Dallessio and Richard E. Weibley},
  journal={Pediatric emergency care},
  volume={10 4},
A 16-month-old male presented with an overdose of Pyridium Plus--a combination anticholinergic, azo dye, and barbiturate--resulting in seizures, coma, and methemoglobinemia. This case report reviews the treatment of methemoglobinemia with methylene blue, activated charcoal, and exchange transfusion. Additionally, the role of the pulse oximeter is addressed when methemoglobinemia exists and is treated with methylene blue. 
Rasburicase Causing Severe Oxidative Hemolysis and Methemoglobinemia in a Patient with Previously Unrecognized Glucose-6-Phosphate Dehydrogenase Deficiency
Patients from ethnicities in which G6 PD deficiency is prevalent at high risk of TLS should be screened for G6PD deficiency prior to administration of rasburicase where practical, and patients recover with conservative measures including supplemental oxygen and packed red cell transfusion.
Methemoglobinemia from Prolonged Therapeutic Use of Phenazopyridine
  • Medicine
  • 2016
An 82-year-old woman who had been taking phenazopyridine at a therapeutic dose for three months when she presented to emergency department with hypoxia was diagnosed with methemoglobinemia, which was corrected with administration of methylene blue.
Clinical Applications of Commonly Used Contemporary Antidotes
The most commonly used antidotes are acetylcysteine, naloxone, atropine, deferoxamine (desferrioxamine) and antivenins, which account for 99% of all antidote use and those agents are reviewed in this article.