Life survival and cardiovascular structures following selective beta-blockade in spontaneously hypertensive rats.

Abstract

The aim of this study was to assess life survival, and arterial and cardiac structural changes following chronic selective beta-blockade in spontaneously hypertensive rats (SHR). Twenty-two SHR aged 3 months and 20 SHR aged 18 months were treated with the beta 1-blocking agent bisoprolol (10 mg/kg/day) or placebo for a period of 2 months. At the end of this… (More)

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