Life-stage-dependent sensitivity of zebrafish (Danio rerio) to estrogen exposure.

@article{Maack2004LifestagedependentSO,
  title={Life-stage-dependent sensitivity of zebrafish (Danio rerio) to estrogen exposure.},
  author={Gerd Maack and Helmut Segner},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2004},
  volume={139 1-3},
  pages={47-55}
}
The aim of this study was to identify periods in zebrafish (Danio rerio) development when estrogen exposure has long-term consequences on reproductive capabilities at the adult stage. To this end, zebrafish were exposed to 10 ng/L ethynylestradiol (EE(2)) during three stages of gonadal differentiation: (i) the juvenile hermaphroditic stage when gonads display the morphology of an immature ovary (in our zebrafish colony this lasted from 15 to 42 days post-fertilization [dpf]), (ii) the gonad… CONTINUE READING

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