Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)

  title={Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)},
  author={Glenn S. Gerhard and Elizabeth J Kauffman and Xujun Wang and Richard Stewart and Jessica L. Moore and Claudia J. Kasales and Eugene Demidenko and Keith C. Cheng},
  journal={Experimental Gerontology},

Figures from this paper

A call to fins! Zebrafish as a gerontological model
It is proposed that the zebrafish is uniquely suited to serve as a bridge model for gerontology, with high fecundity and economical husbandry requirements, facilitating large‐scale approaches including demographic studies and mutagenesis screens.
Functional Aging and Gradual Senescence in Zebrafish
  • S. Kishi
  • Biology
    Annals of the New York Academy of Sciences
  • 2004
Using those biological and biochemical aging markers already characterized in normal zebrafish, transgenic fish analyses and genetic mutant fish screens can be readily performed to elucidate the role and molecular mechanisms of common or different pathways of aging among vertebrates from fish to humans and also will contribute to the discovery of potential drugs applicable to age‐associated diseases in the future.
Zebrafish as a Genetic Model in Biological and Behavioral Gerontology: Where Development Meets Aging in Vertebrates – A Mini-Review
It is suggested that the zebrafish genetic model offers a unique opportunity to fill in this gap in understanding the molecular mechanisms of aging and in developing preventive and therapeutic strategies to prolong the productive life span (‘health span’) in humans.
The use of mature zebrafish (Danio rerio) as a model for human aging and disease.
  • E. Keller, J. Murtha
  • Biology, Psychology
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
  • 2004
Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
New zebrafish models for a human premature aging disorder are generated and the utility for studying laminopathies is demonstrated, which may provide a new platform for future drug screening as well as genetic analyses aimed at identifying modifier genes that influence not only progeria and laminationopathies but also other age-associated human diseases common in vertebrates.
Functional alterations and transcriptomic changes during zebrafish cardiac aging
It is discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function.
Life-long preservation of the regenerative capacity in the fin and heart in zebrafish
It is demonstrated that zebrafish preserve a life-long regenerative ability of the caudal fin and heart, and the expression of epicardial genes in response to heart injury was comparable in two groups.


Ageing in fishes.
The results tentatively support the contention of commonality in mechanism of ageing processes in vertebrate species showing gradual senescence.
Longevity, senescence, and the genome
By comparing species that have different developmental and life spans, Finch proposes a typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)
The feasibility of the zebrafish as an experimental model for the study of skin tumors is established and the incidence of tumors in ENU-treated fish is compared with untreated controls.
Genetic dissection of vertebrate processes in the zebrafish: a comparison of uniparental and two-generation screens.
  • K. Cheng, J. L. Moore
  • Biology
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 1997
Gynogenetic half-tetrad screens are genetically robust and technically accessible to the independent researcher and can be used to address a broad range of questions in vertebrate biology.
Biodemographic trajectories of longevity.
Three biodemographic insights--concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality--offer clues and suggest research on the failure of complicated systems, on new demographic equations for evolutionary theory, and on fertility-longevity interactions.
Zebrafish Earns Its Stripes in Genetic Screens
Researchers are using various clever techniques to identify zebrafish mutants with which to probe the genes involved in a wide variety of human maladies, from obesity to bone diseases.
A genetic screen for mutations affecting embryogenesis in zebrafish.
The results from the first application of such a large-scale genetic screening to vertebrate development of mutagenized zebrafish demonstrate that mutations affecting a variety of developmental processes can be efficiently recovered from zebra fish.
Age at sexual maturity and its relationship to longevity in the male annual cyprinodont fish, Nothobranchius guenther.
Effective targeted gene ‘knockdown’ in zebrafish
It is shown here that antisense, morpholino-modified oligonucleotides (morpholinos) are effective and specific translational inhibitors in zebrafish, and conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebra fish embryos.
Longevity in fish: some ecological and evolutionary considerations.
  • R. Beverton
  • Environmental Science
    Basic life sciences
  • 1987
The present symposium in its aims and multi-disciplinary character has much in common with the 1959 CIBA Conference, and the author shall again approach his subject primarily from the demographic standpoint, but this time exploring certain evolutionary implications.