Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)
@article{Gerhard2002LifeSA, title={Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)}, author={Glenn S. Gerhard and Elizabeth J Kauffman and Xujun Wang and Richard Stewart and Jessica L. Moore and Claudia J. Kasales and Eugene Demidenko and Keith C. Cheng}, journal={Experimental Gerontology}, year={2002}, volume={37}, pages={1055-1068} }
217 Citations
A call to fins! Zebrafish as a gerontological model
- BiologyAging cell
- 2002
It is proposed that the zebrafish is uniquely suited to serve as a bridge model for gerontology, with high fecundity and economical husbandry requirements, facilitating large‐scale approaches including demographic studies and mutagenesis screens.
Functional Aging and Gradual Senescence in Zebrafish
- BiologyAnnals of the New York Academy of Sciences
- 2004
Using those biological and biochemical aging markers already characterized in normal zebrafish, transgenic fish analyses and genetic mutant fish screens can be readily performed to elucidate the role and molecular mechanisms of common or different pathways of aging among vertebrates from fish to humans and also will contribute to the discovery of potential drugs applicable to age‐associated diseases in the future.
The zebrafish as a vertebrate model of functional aging and very gradual senescence
- BiologyExperimental Gerontology
- 2003
Zebrafish as a Genetic Model in Biological and Behavioral Gerontology: Where Development Meets Aging in Vertebrates – A Mini-Review
- BiologyGerontology
- 2009
It is suggested that the zebrafish genetic model offers a unique opportunity to fill in this gap in understanding the molecular mechanisms of aging and in developing preventive and therapeutic strategies to prolong the productive life span (‘health span’) in humans.
The use of mature zebrafish (Danio rerio) as a model for human aging and disease.
- Biology, PsychologyComparative biochemistry and physiology. Toxicology & pharmacology : CBP
- 2004
Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
- Biology, MedicinePloS one
- 2011
New zebrafish models for a human premature aging disorder are generated and the utility for studying laminopathies is demonstrated, which may provide a new platform for future drug screening as well as genetic analyses aimed at identifying modifier genes that influence not only progeria and laminationopathies but also other age-associated human diseases common in vertebrates.
Functional alterations and transcriptomic changes during zebrafish cardiac aging
- Biology, MedicineBiogerontology
- 2020
It is discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function.
Life-long preservation of the regenerative capacity in the fin and heart in zebrafish
- BiologyBiology Open
- 2012
It is demonstrated that zebrafish preserve a life-long regenerative ability of the caudal fin and heart, and the expression of epicardial genes in response to heart injury was comparable in two groups.
The zebrafish as a gerontology model in nervous system aging, disease, and repair
- BiologyAgeing Research Reviews
- 2015
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