Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age.

Abstract

Life span can be extended in rodents by restricting food availability (caloric restriction [CR]) or by providing food low in methionine (Meth-R). Here, we show that a period of food restriction limited to the first 20 days of life, via a 50% enlargement of litter size, shows extended median and maximal life span relative to mice from normal sized litters… (More)
DOI: 10.1093/gerona/glp051

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Cite this paper

@article{Sun2009LifespanEI, title={Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age.}, author={Liou Y Sun and Amir A. Sadighi Akha and Richard A. Miller and James Harper}, journal={The journals of gerontology. Series A, Biological sciences and medical sciences}, year={2009}, volume={64 7}, pages={711-22} }