Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space.

@article{Payne2003LifelongCR,
  title={Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space.},
  author={Anthony Michael Payne and S. L. Dodd and Christiaan Leeuwenburgh},
  journal={Journal of applied physiology},
  year={2003},
  volume={95 6},
  pages={2554-62}
}
The decline in muscle function is associated with an age-related decrease in muscle mass and an age-related decline in strength. However, decreased strength is not solely due to decreased muscle mass. The age-related decline in muscle-specific force (force/muscle cross-sectional area), a measure of intrinsic muscle function, also contributes to age-related strength decline, and the mechanisms by which this occurs are only partially known. Moreover, changes in the extracellular space could have… CONTINUE READING