Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.

Abstract

A normal hemostatic response to vascular injury requires both factor VIII (FVIII) and von Willebrand factor (VWF). In plasma, VWF and FVIII normally circulate as a noncovalent complex, and each has a critical function in the maintenance of hemostasis. Furthermore, the interaction between VWF and FVIII plays a crucial role in FVIII function, immunogenicity… (More)
DOI: 10.1182/blood-2016-04-713289

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Cite this paper

@article{Pipe2016LifeIT, title={Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.}, author={Steven W Pipe and Robert R. Montgomery and Kathleen P Pratt and Peter J. Lenting and David P. Lillicrap}, journal={Blood}, year={2016}, volume={128 16}, pages={2007-2016} }