Life in acid: pH homeostasis in acidophiles.

  title={Life in acid: pH homeostasis in acidophiles.},
  author={Craig Baker-Austin and Mark Dopson},
  journal={Trends in microbiology},
  volume={15 4},
Microorganisms that have a pH optimum for growth of less than pH 3 are termed "acidophiles". To grow at low pH, acidophiles must maintain a pH gradient of several pH units across the cellular membrane while producing ATP by the influx of protons through the F(0)F(1) ATPase. Recent advances in the biochemical analysis of acidophiles coupled to sequencing of several genomes have shed new insights into acidophile pH homeostatic mechanisms. Acidophiles seem to share distinctive structural and… CONTINUE READING
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