Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals

@article{vanSighem2010LifeEO,
  title={Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals},
  author={Ard van Sighem and Luuk Gras and Peter Reiss and Kees Brinkman and Frank de Wolf},
  journal={AIDS},
  year={2010},
  volume={24},
  pages={1527–1535}
}
Objective:To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population. Design:National observational HIV cohort in the Netherlands. Methods:Four thousand, six hundred and twelve patients diagnosed with HIV between 1998 and 2007 and still antiretroviral therapy-naive as of 24 weeks after diagnosis were selected. Progression to death compared to the age and sex-matched general population was studied with… 
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398 Citations
Highly Influential Citations
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398 Citations

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References

SHOWING 1-10 OF 34 REFERENCES
Mortality and progression to AIDS after starting highly active antiretroviral therapy
TLDR
Survival probabilities were high among HIV-infected patients initiating HAART at an early stage of infection, and the best therapy strategy is therefore to startHAART at this stage of infections, however, deferring HAART in patients with high CD4 cell counts may be clinically more appropriate given toxicity and adherence problems.
Survival of Persons with and without HIV Infection in Denmark, 19952005
TLDR
This study estimates median survival and age-specific mortality rates for an entire HIV-infected population compared with a cohort from the general population in Denmark, with continuous enrollment of both newly diagnosed residents and immigrants with existing HIV infection.
Estimating the proportion of patients infected with HIV who will die of comorbid diseases.
Mortality in Patients With Successful Initial Response to Highly Active Antiretroviral Therapy Is Still Higher Than in Non-HIV-Infected Individuals
TLDR
Mortality in HIV-infected patients with a good initial response to HAART is still higher than in the general population, despite the introduction of highly active antiretroviral therapy.
Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy
TLDR
A significant and progressive decrease in mortality and increase in life expectancy were observed over the 12-year study period and were directly associated with the use of modern forms of HAART.
Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population
TLDR
HIV-infected patients starting highly active antiretroviral therapy (HAART) with a CD4 cell count above 200 × 106 cells/l had low mortality rates that were comparable with the rates found in other chronic medical diseases.
Improved survival in HIV-infected persons: consequences and perspectives.
TLDR
Despite the improvements in antiretroviral therapy, there is still an excess mortality among HIV patients, which appears to be only partially attributable to immunodeficiency, with lifestyle factors potentially playing a pronounced role, so an effort to further increase survival must target risk factors for both HIV-related and -unrelated mortality.
Prognostic importance of initial response in HIV-1 infected patients starting potent antiretroviral therapy: analysis of prospective studies
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies
Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
...
...