Life expectancy living with HIV: recent estimates and future implications

@article{Nakagawa2013LifeEL,
  title={Life expectancy living with HIV: recent estimates and future implications},
  author={Fumiyo Nakagawa and Margaret T. May and Andrew N Phillips},
  journal={Current Opinion in Infectious Diseases},
  year={2013},
  volume={26},
  pages={17–25}
}
Purpose of review The life expectancy of people living with HIV has dramatically increased since effective antiretroviral therapy has been available, and still continues to improve. Here, we review the latest literature on estimates of life expectancy and consider the implications for future research. Recent findings With timely diagnosis, access to a variety of current drugs and good lifelong adherence, people with recently acquired infections can expect to have a life expectancy which is… 
Life Expectancy after Initiation of Combination Antiretroviral Therapy in Thailand
TLDR
increasing life expectancy with higher baseline CD4+ T-cell counts supports the guideline recommendations to start cART irrespective of CD4+, and is beneficial to forecast the treatment cost and develop health policies for people living with HIV in Thailand and Asia.
End-of-Life Planning Prior to Death Among People Living With HIV.
TLDR
Rates of completed ADorMPOAassignment are low in the general population but tend to be completed well in advance of death, and prior ACP was linked to better patient and family satisfaction, quality of life, or quality of death and dying.
Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada
TLDR
A 20-year-old HIV-positive adult on ART in the U.S. or Canada is expected to live into their early 70 s, a life expectancy approaching that of the general population.
What influences quality of life in older people living with HIV?
TLDR
The findings indicate that concerns about memory difficulties, anxiety and depression, as well as gender, ethnicity, financial factors, and relationship status, are important contributors to quality of life in older people living with HIV.
Achieving the fourth 90: healthy aging for people living with HIV
TLDR
A critical priority is to aim for healthy aging among people living with HIV (PLWH) in order to reach the UNAIDS 90– 90–90 targets, an achievement that some have called ‘the 4th 90’.
HIV Treatment
TLDR
The outlook for people living with HIV (PLWH) has been transformed by the availability of effective antiretroviral therapy, but patients are at a higher risk of several age-related co-morbidities, anxiety, depression, and stigma and discrimination.
Empirical estimation of life expectancy from a linked health database of adults who entered care for HIV
TLDR
Use of age limits less than the expected age at death for the open-ended age group significantly overstates the estimated LE and is not recommended.
Health-related quality of life and associated factors in adults living with HIV in Rwanda
TLDR
The results of this study reveal that behavioural and biological risk factors for NCDs were significantly associated with a lower HRQOL, and certain socio-demographic and HIV-related variables – specifically being unmarried, lack of HIV disclosure and low CD4 count – were associated with significantly lower mental and physical dimensions of quality of life.
The road to success. Long-term prognosis for persons living with HIV in Denmark - time trends and risk factors.
  • N. Lohse
  • Medicine
    Danish medical journal
  • 2016
TLDR
Despite the overall positive trends in virological failure and drug-resistance development at the population level, the findings underline the crucial importance of always having an effective treatment option available for the individual patient with drug-resistant virus.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 92 REFERENCES
Projected life expectancy of people with HIV according to timing of diagnosis
TLDR
If low rates of virologic failure observed in treated patients continue, predicted life expectancy is relatively high in people with HIV who can access a wide range of antiretrovirals.
Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia
TLDR
There are substantial disparities in life expectancy for persons living with HIV in British Columbia, and members of the injection drug community, particularly those who are not taking HAART, experience elevated mortality in comparison with those without a history of drug use.
Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
TLDR
Life expectancy in people treated for HIV infection has increased by over 15 years during 1996-2008, but is still about 13 years less than that of the UK population.
Life Expectancy of Persons Receiving Combination Antiretroviral Therapy in Low-Income Countries: A Cohort Analysis From Uganda
TLDR
Ugandan patients receiving cART can expect an almost normal life expectancy, although there is considerable variability among subgroups of patients.
Life Expectancy After HIV Diagnosis Based on National HIV Surveillance Data From 25 States, United States
TLDR
Disparity in life expectancy for females and both black and Hispanic males, compared with males and white males, respectively, persists and should be addressed.
Survival of Persons with and without HIV Infection in Denmark, 19952005
TLDR
This study estimates median survival and age-specific mortality rates for an entire HIV-infected population compared with a cohort from the general population in Denmark, with continuous enrollment of both newly diagnosed residents and immigrants with existing HIV infection.
Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
TLDR
The life expectancy of asymptomatic HIV-infected patients who are still treatment-naive and have not experienced a CDC-B or C event at 24 weeks after diagnosis approaches that of non- Infected individuals, however, follow-up time is short compared to the expected number of years lived.
Influence of Alternative Thresholds for Initiating HIV Treatment on Quality-Adjusted Life Expectancy: A Decision Model
TLDR
This computer simulation estimated that starting treatment earlier would provide greater unadjusted and quality-adjusted life expectancy than starting it later for all patients age 30 years and for patients age 40 years who have a viral load greater than 30000 copies/mL.
HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity
#### Summary points More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). Most patients who take medication achieve durable
...
1
2
3
4
5
...