Life and death of neurons in the aging brain.

  title={Life and death of neurons in the aging brain.},
  author={John Morrison and Patrick R. Hof},
  volume={278 5337},
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of… CONTINUE READING
Highly Cited
This paper has 578 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 258 extracted citations

Growth hormone and aging.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen • 2003
View 8 Excerpts
Highly Influenced

Corticolimbic interactions associated with performance on a short-term memory task are modified by age.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 4 Excerpts
Highly Influenced

578 Citations

Citations per Year
Semantic Scholar estimates that this publication has 578 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-4 of 4 references

Nature 388, 272 (1997)

C. A. Barnes, M. S. Suster, J. Shen, B. J. McNaughton
SCIENCE z VOL. 278 z 17 OCTOBER • 1997
View 3 Excerpts
Highly Influenced


M. S. Albert
Natl. Acad. Sci. U.S.A. 93, • 1354
View 3 Excerpts
Highly Influenced

The Role of Ovarian Hormones in Cognition and Dementia,

H. Fillit
Proc. Natl. Acad. Sci. U.S.A • 1996
View 1 Excerpt

Cortical Function, Including Hippocampus, vol. 6 of Cerebral Cortex

D. L. Rosene, G. W. Van Hoesen
New York, • 1987
View 2 Excerpts