Life and death of a cardiac calcium spark

  title={Life and death of a cardiac calcium spark},
  author={Michael D. Stern and Eduardo R{\'i}os and Victor A. Maltsev},
  booktitle={The Journal of general physiology},
Calcium sparks in cardiac myocytes are brief, localized calcium releases from the sarcoplasmic reticulum (SR) believed to be caused by locally regenerative calcium-induced calcium release (CICR) via couplons, clusters of ryanodine receptors (RyRs). How such regeneration is terminated is uncertain. We performed numerical simulations of an idealized stochastic model of spark production, assuming a RyR gating scheme with only two states (open and closed). Local depletion of calcium in the SR was… CONTINUE READING
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