Life and death by death receptors.

@article{Guicciardi2009LifeAD,
  title={Life and death by death receptors.},
  author={Maria Eugenia Guicciardi and Gregory James Gores},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 6},
  pages={
          1625-37
        }
}
Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the "death domain" that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation and recruitment of adaptor proteins, which, in turn, initiates a proteolytic cascade by recruiting and activating initiator caspases 8 and 10. Death receptors were once thought to primarily induce cytotoxic… CONTINUE READING

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