Life and death: metabolic rate, membrane composition, and life span of animals.

@article{Hulbert2007LifeAD,
  title={Life and death: metabolic rate, membrane composition, and life span of animals.},
  author={A. Hulbert and R. Pamplona and R. Buffenstein and W. Buttemer},
  journal={Physiological reviews},
  year={2007},
  volume={87 4},
  pages={
          1175-213
        }
}
Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is called the rate-of-living theory of aging and lies at the base of the oxidative-stress theory of aging, currently the most generally accepted explanation of aging. However, the rate-of-living theory of… Expand
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References

SHOWING 1-10 OF 405 REFERENCES
On the importance of fatty acid composition of membranes for aging.
  • A. Hulbert
  • Biology, Medicine
  • Journal of theoretical biology
  • 2005
The membrane pacemaker theory of aging is an extension of the oxidative stress theory of aging. It emphasises variation in the fatty acid composition of membranes as an important influence on lipidExpand
Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span
TLDR
The physiological meaning of these findings and the effects of experimental manipulations such as dietary stress, caloric restriction, and endocrine control in relation to aging and longevity are discussed. Expand
The links between membrane composition, metabolic rate and lifespan.
  • A. Hulbert
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2008
TLDR
The "membrane pacemaker" theory of metabolism proposes that highly polyunsaturated acyl chains impart physical properties to membrane bilayers that enhance and speed up the molecular activity of membrane proteins and consequently the metabolic activity of cells, tissues and the whole animal. Expand
Rate of generation of oxidative stress-related damage and animal longevity.
  • G. Barja
  • Biology, Medicine
  • Free radical biology & medicine
  • 2002
TLDR
Comparative studies about the relationship between endogenous antioxidant and pro-oxidant factors and maximum longevity of different animal species are reviewed and suggest that the rate of generation of endogenous oxidative damage determines, at least in part, the rates of aging in animals. Expand
Effect of age and metabolic rate on lipid peroxidation in the housefly, Musca domestica L.
TLDR
The results suggest that accelerated senescence associated with higher metabolic rates, increases the rate of age-associated decline in the ability of houseflies to counteract lipid peroxidation in vitro. Expand
Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.
TLDR
The ratio of superoxide dismutase specific activity to specific metabolic rate of the tissue or of the whole adult organism was found to increase with increasing maximum lifespan potential for all the species, suggesting that longer-lived species have a higher degree of protection against by-products of oxygen metabolism. Expand
Minireview: the role of oxidative stress in relation to caloric restriction and longevity.
TLDR
Recent reports of caloric restriction and longevity are reviewed, focusing on mitochondrial oxidative stress and the proposed mechanisms leading to an extended longevity in calorie-restricted animals. Expand
Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.
  • R. Cutler
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1985
TLDR
Kinetic analysis of the data indicates that the amount of peroxidizable substrate was the major factor determining the rate of autoxidation, and the hypothesis that aging may be caused in part by oxygen radicals initiating peroxidation reactions is supported. Expand
Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice.
TLDR
Naked mole-rat peroxidation indices, calculated from muscle and liver mitochondrial membranes, concur with those predicted by MLS rather than by body size, suggesting that membrane phospholipid composition is an important determinant of longevity. Expand
Is the mitochondrial free radical theory of aging intact?
TLDR
Comparative studies consistently show that long-lived mammals and birds have low rates of mitochondrial reactive oxygen species (ROS) production and low levels of oxidative damage in their mitochondrial DNA, which is consistent with the predictions of the mitochondrial free radical theory of aging. Expand
...
1
2
3
4
5
...