Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use.

  title={Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use.},
  author={Jeffrey G. Scott},
  journal={Annual review of entomology},
  • J. G. Scott
  • Published 7 January 2019
  • Biology
  • Annual review of entomology
The voltage-sensitive sodium channel (VSSC) is a critical component of the insect nervous system. Pyrethroids and DDT are insecticides that have been widely used, and they kill insects by perturbations of the VSSC. Decades of insecticide use selected for mutations in Vssc that give rise to resistance in almost all pest insects. However, the mutations responsible for the resistance are not always the same, and some unusual patterns have emerged. This review focuses on what pyrethroid/DDT… 

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