Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use.

@article{Scott2019LifeAD,
  title={Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use.},
  author={Jeffrey G. Scott},
  journal={Annual review of entomology},
  year={2019},
  volume={64},
  pages={
          243-257
        }
}
  • J. G. Scott
  • Published 7 January 2019
  • Biology
  • Annual review of entomology
The voltage-sensitive sodium channel (VSSC) is a critical component of the insect nervous system. Pyrethroids and DDT are insecticides that have been widely used, and they kill insects by perturbations of the VSSC. Decades of insecticide use selected for mutations in Vssc that give rise to resistance in almost all pest insects. However, the mutations responsible for the resistance are not always the same, and some unusual patterns have emerged. This review focuses on what pyrethroid/DDT… 

Conservation of the voltage‐sensitive sodium channel protein within the Insecta

TLDR
Overall, this study shows that, overall, Vssc is highly conserved across Insecta and within a population of an insect, but that important differences do exist.

Association of voltage-gated sodium channel mutations with field-evolved pyrethroid resistant phenotypes in soybean aphid and genetic markers for their detection

TLDR
A strong association was revealed between aphids with L1014F and M918I vgsc mutations and survival following exposure to pyrethroids, and it is discussed how generating these types of data could improve efforts to mitigate the effects of pyrethroid resistance on crop production.

The F1534C voltage‐sensitive sodium channel mutation confers 7‐ to 16‐fold resistance to pyrethroid insecticides in Aedes aegypti

TLDR
The F1534C Vssc mutation is common in A. aegypti populations and confers 7‐ to 16‐fold resistance to pyrethroids, DDT, and DCJW in Aedes aeEgypti, considerably less than previously reported for the S989P+V1016G mutations.

Compensatory mechanisms in resistant Anopheles gambiae AcerKis and KdrKis neurons modulate insecticide-based mosquito control

TLDR
Using multidisciplinary approaches adapted to neurons isolated from resistant Anopheles gambiae AcerKis and KdrKis strains together with larval bioassays, it is demonstrated that nAChRs, and the intracellular calcium concentration represent the key components of an adaptation strategy ensuring neuronal functions maintenance.

Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti

TLDR
The phylogenetic analysis of Vssc supported multiple independent origins of the F1534C mutation and corroborated previous geographic distributions of resistance mutations and provided evidence for both recombination and sequential accumulation of mutations contributing to the molecular evolution of resistance alleles in A. aegypti.

Detection of the Nav channel kdr-like mutation and modeling of factors affecting survivorship of Culex quinquefasciatus mosquitoes from six areas of Harris County (Houston), Texas, after permethrin field-cage tests

Culex quinquefasciatus is one of the most important mosquito vectors of arboviruses. Currently, the fastest approach to control disease transmission is the application of synthetic adulticide

Pyrethroid Resistance and Fitness Cost Conferred by the super-kdr Mutation M918L in Rhopalosiphum padi (Hemiptera: Aphididae)

TLDR
The results indicated that M918L-mediated resistance showed a significant fitness cost in the presence of wild aphids without insecticide pressure, strongly correlated with the initial resistance allele frequency.

Levels of cross-resistance to pyrethroids conferred by the Vssc knockdown resistance allele 410L+1016I+1534C in Aedes aegypti

TLDR
This study found that a kdr (410L+V1016I+1534C) allele was the main mechanism of resistance in a pyrethroid-resistant strain of A. aegypti collected in Colombia and the importance of these results to understand the evolution of insecticide resistance and mosquito control is discussed.

Evaluation of insecticide efficacy and insecticide adaptive response in Italian populations of Drosophila suzukii

TLDR
It is suggested that spotted wing drosophila, upon continued selective pressure, are more prone to develop low resistance to cyantraniliprole and deltamethrin than spinosad.