Life Redesigned To Suit the Engineering Crowd Evolution is not fast or efficient enough for engineers who plan to move blocks of genes around as routinely as they do electronic parts
@inproceedings{ngineers2006LifeRT, title={Life Redesigned To Suit the Engineering Crowd Evolution is not fast or efficient enough for engineers who plan to move blocks of genes around as routinely as they do electronic parts}, author={E ngineers and Drew Endy}, year={2006} }
E ngineers known as biosynthesists are leading a revolution in molecular biology. Instead of old-fashioned genetic engineering—last generation’s revolution—where one gene at a time is moved between microbial species, these engineers have far more radical plans. At this early stage, for instance, they are mixing genes from several different organisms to build whole new metabolic pathways and novel microbes. Some biosynthesists even expect to rewrite the genetic code altogether, designing…
References
SHOWING 1-10 OF 10 REFERENCES
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.
- BiologyAnnual review of biochemistry
- 2006
This work focuses on the question of how the remarkably diverse array of eukaryotic signaling circuits may have evolved and shows that such modular systems can be exploited to engineer nonnatural signaling proteins and pathways with novel behavior.
Expanding the Genetic Code
- Biology, ChemistryScience
- 2003
This methodology provides a powerful tool both for exploring protein structure and function in vitro and in vivo and for generating proteins with new or enhanced properties.
Essential genes of a minimal bacterium.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2006
Using global transposon mutagenesis, this work identifies 382 of the 482 M. genitalium protein-coding genes as essential, plus five sets of disrupted genes that encode proteins with potentially redundant essential functions, such as phosphate transport.
Environmentally controlled invasion of cancer cells by engineered bacteria.
- BiologyJournal of molecular biology
- 2006
Production of ethanol from cellulosic biomass hydrolysates using genetically engineered saccharomyces yeast capable of cofermenting glucose and xylose
- Biology, MedicineApplied biochemistry and biotechnology
- 2004
It is demonstrated that the stable recombinant Sacharomyces yeast, 424A (LNH-ST), which contains the cloned xylose-metabolizing genes stably integrated into the yeast chromosome in high copy numbers, can efficiently ferment glucose andxylose present in hydrolysates from different cellulosic biomass to ethanol.
Environmental Genome Shotgun Sequencing of the Sargasso Sea
- BiologyScience
- 2004
Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity.
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
- BiologyNature
- 2006
The engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l-1) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase from A. annua that performs a three-step oxidation of amorpha-4,11-diene to art Artemisinic acid.
Refactoring bacteriophage T7. Mol. Systems Biol
- Refactoring bacteriophage T7. Mol. Systems Biol
- 2005
The promise and perils of synthetic biology. The New Atlantis
- The promise and perils of synthetic biology. The New Atlantis
- 2006