• Corpus ID: 16382681

Life Extension Pseudoscience and the SENS Plan

  title={Life Extension Pseudoscience and the SENS Plan},
  author={Preston W. Estep and Matt Kaeberlein},
Recent scientific advances have taken gerontological research to challenging and exciting new frontiers, and have given many scientists increased confidence that human aging is to some degree controllable. We have been on the front lines of some of these developments and the speculative discussions they have engendered, and we are proud to be part of the increasingly productive biomedical effort to reduce the pathologies of aging, and age-associated diseases, to the greatest degree possible—and… 
Engineering Substantially Prolonged Human Lifespans: Biotechnological Enhancement and Ethics
Substantial extension of the human lifespan has recently become a subject of lively debate. One reason for this is the completion in 2001 of the Human Genome Project and the experimental avenues for
The Natural Biogerontology Portfolio
Abstract:  The early days of biogerontology were blessed with an undiluted forthrightness concerning the field's ultimate goals, epitomized by its leaders. Luminaries from Pearl to Comfort to
The natural biogerontology portfolio: "defeating aging" as a multi-stage ultra-grand challenge.
  • A. D. de Grey
  • Medicine
    Annals of the New York Academy of Sciences
  • 2007
Biogerontologists are in a position to explain that the disparate strands of contemporary biomedical gerontology are not in conflict, but rather that they constitute a portfolio of approaches with a range of potential efficacies and degrees of difficulty of implementation, which can save more lives together than any can save individually, and all of which thus merit intensive pursuit.
An important question related to the ethical discussion on considerable life extension is whether longevity is valuable in itself. Prolongetivism is the view that supports considerable extension of
Ray Kurzweil and Uploading: Just Say No!
There is a debate about the possibility of mind-uploading – a process that purportedly transfers human minds and therefore human identities into computers. This paper bypasses the debate about the
Transhumanisms: A Review of Transhumanist Schools of Thought
Transhumanism is a philosophical system that proposes the use of advanced technologies directly in the human body to modify and improve its biological condition. That is the core idea of
The Promise of Human Life Span Extension


Time to Talk SENS: Critiquing the Immutability of Human Aging
This work surveys the major categories of damage and the ways in which, with current or foreseeable biotechnology, they could be reversed, implying that indefinite postponement of aging—which is termed “engineered negligible senescence”—may be within sight.
Science fact and the SENS agenda
In an article published in the EMBO reports Special Issue on Time and Ageing, Aubrey D.N.J. de Grey criticizes biogerontologists for what he sees as their generally pessimistic view of the
Like it or not, life-extension research extends beyond biogerontology.
In this issue of EMBO reports, Warner and 27 other biogerontologists dismiss strategies for engineered negligible senescence (SENS) as ‘scientifically’ unrealistic (Warner et al, 2005); like Kelvin, they forget that engineering differs profoundly from science in its goals, methods and skills.
Medical bioremediation: Prospects for the application of microbial catabolic diversity to aging and several major age-related diseases
How microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects are discussed.
Resistance to debate on how to postpone ageing is delaying progress and costing lives
Their field is passing up the opportunity to elevate itself to its rightful level of public appreciation and investment, with the result that much longer healthy lives are being denied those who will die before ‘real anti-ageing medicine’ arrives unless the authors start working harder towards it now.
Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention.
Here, it is described why WILT might prove to be an exceptionally powerful anti-cancer modality.
Total Deletion of in Vivo Telomere Elongation Capacity: An Ambitious but Possibly Ultimate Cure for All Age‐Related Human Cancers
It is argued that a whole‐body gene‐deletion approach, however bizarre it initially seems, is truly the only way to overcome the hypermutation that makes tumors so insidious and advocated working toward such a therapy.
Large genome rearrangements as a primary cause of aging
A model for an aging tissue is designed in terms of a cellular mosaic with a gradual increase in genome rearrangements that leads to functional senescence, neoplastic transformation or death of individual cells by disrupting nuclear architecture and patterns of gene regulation.
Epigenetic drift in aging identical twins.
  • G. Martin
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
Gene Expression Studies Reflect Increase in Variation Between Twin Pairs asThey Age in this issue of PNAS, a group of Span-ish, Swedish, Danish, English, andAmerican investigators report their find-ings of both global and locus-specificdifferences in DNA methylation andhistone acetylation in identical twins ofvarious ages.
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
A critical role for telomere length in the overall fitness, reserve, and well being of the aging organism is demonstrated.