Life Cycle Analysis of Kidney Gene Expression in Male F344 Rats

@inproceedings{Kwekel2013LifeCA,
  title={Life Cycle Analysis of Kidney Gene Expression in Male F344 Rats},
  author={Joshua C. Kwekel and Varsha G. Desai and Carrie L. Moland and Vikrant Vijay and James C. Fuscoe},
  booktitle={PloS one},
  year={2013}
}
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs. Age-related differences in kidney biology, therefore, are a key concern in understanding drug safety and disease progression. We hypothesize that the underlying suite of genes expressed in the kidney at various life cycle stages will impact susceptibility to adverse drug reactions. Therefore, establishing changes in… CONTINUE READING
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