Life‐Threatening Bradyarrhythmia After Massive Azithromycin Overdose
@article{Tilelli2006LifeThreateningBA, title={Life‐Threatening Bradyarrhythmia After Massive Azithromycin Overdose}, author={J. Tilelli and K. M. Smith and R. Pettignano}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={2006}, volume={26} }
A 9‐month‐old infant was inadvertently administered azithromycin 50 mg/kg, taken from floor stock, instead of the prescribed ceftriaxone. Shortly thereafter, she became unresponsive and pulseless. The initial heart rhythm observed when cardiopulmonary resuscitation was started was a wide‐complex bradycardia, with a prolonged rate‐corrected QT interval and complete heart block. The baby was resuscitated with epinephrine and atropine, but she suffered severe anoxic encephalopathy. Torsade de… CONTINUE READING
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References
SHOWING 1-10 OF 22 REFERENCES
Verapamil Toxicity Resulting from a Probable Interaction with Telithromycin
- Medicine
- The Annals of pharmacotherapy
- 2005
- 24
Erythromycin induced Torsades de Pointes: case report and review of the literature.
- Medicine
- South Dakota journal of medicine
- 1994
- 18
Is azithromycin treatment associated with prolongation of the Q-Tc interval?
- Medicine
- Wiener klinische Wochenschrift
- 2002
- 25
Possible risk for cardiac arrhythmia related to intravenous erythromycin
- Medicine
- Intensive Care Medicine
- 2005
- 23
Erythromycin-induced QT prolongation and polymorphic ventricular tachycardia (torsades de pointes): case report and review.
- Medicine
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 1994
- 58
Comparative Pharmacodynamic Analysis of Q-T Interval Prolongation Induced by the Macrolides Clarithromycin, Roxithromycin, and Azithromycin in Rats
- Medicine
- Antimicrobial Agents and Chemotherapy
- 2000
- 89
- PDF
Milrinone Facilitates Resuscitation From Cardiac Arrest and Attenuates Postresuscitation Myocardial Dysfunction
- Medicine
- Circulation
- 2003
- 33
- PDF