Life‐Threatening Bradyarrhythmia After Massive Azithromycin Overdose

@article{Tilelli2006LifeThreateningBA,
  title={Life‐Threatening Bradyarrhythmia After Massive Azithromycin Overdose},
  author={John Arthur Tilelli and Kathleen M. Smith and Robert Pettignano},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2006},
  volume={26}
}
A 9‐month‐old infant was inadvertently administered azithromycin 50 mg/kg, taken from floor stock, instead of the prescribed ceftriaxone. Shortly thereafter, she became unresponsive and pulseless. The initial heart rhythm observed when cardiopulmonary resuscitation was started was a wide‐complex bradycardia, with a prolonged rate‐corrected QT interval and complete heart block. The baby was resuscitated with epinephrine and atropine, but she suffered severe anoxic encephalopathy. Torsade de… 
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  • J. MontnachI. BaróF. CharpentierM. De WaardG. Loussouarn
  • Medicine, Biology
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2021
The easy-to-use O'Hara-Rudy model can be applied to assess the QT-prolongation potential of off-label drugs, beyond HCQ and AZM, in different conditions representative of COVID-19 patients and to evaluate the potential impact of additional drug used to limit the arrhythmogenic risk.

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