Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart.

@article{Ebel2001LidocaineRI,
  title={Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart.},
  author={Dirk Ebel and Peter Lipfert and Jan Fraessdorf and Benedikt Preckel and Jost M{\"u}llenheim and Volker Thaemer and Wolfgang Schlack},
  journal={British journal of anaesthesia},
  year={2001},
  volume={86 6},
  pages={
          846-52
        }
}
The local anaesthetic lidocaine protects the myocardium in ischaemia-reperfusion situations. It is not known if this is the consequence of an anti-ischaemic effect or an effect on reperfusion injury. Therefore, we investigated the effect of two concentrations of lidocaine on myocardial ischaemia-reperfusion injury and on reperfusion injury alone. We used an isolated rat heart model where heart rate, ventricular volume and coronary flow were kept constant. Hearts underwent 45 min of low-flow… CONTINUE READING

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