Lidocaine oxidation by electrogenerated reactive oxygen species in the light of oxidative drug metabolism.

@article{NouriNigjeh2010LidocaineOB,
  title={Lidocaine oxidation by electrogenerated reactive oxygen species in the light of oxidative drug metabolism.},
  author={Eslam Nouri-Nigjeh and Hjalmar P. Permentier and Rainer Bischoff and Andries P. Bruins},
  journal={Analytical chemistry},
  year={2010},
  volume={82 18},
  pages={7625-33}
}
The study of oxidative drug metabolism by Cytochrome P450s (P450) is important in the earlier stages of drug development. For this purpose, automated analytical techniques are needed for fast and accurate estimation of oxidative drug metabolism. Previous studies have shown that electrochemistry in combination with mass spectrometry is a versatile analytical technique to generate drug metabolites that result from direct electron transfer. Here we show that electrochemical generation of reactive… CONTINUE READING