Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.

@article{Lahav2002LidocaineIS,
  title={Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.},
  author={Maor Lahav and Mia Levite and Luigi Bassani and Alon Lang and Henk Fidder and Ruth Tal and Simon Bar-Meir and Lloyd Hitoshi Mayer and Yehuda Chowers},
  journal={Clinical and experimental immunology},
  year={2002},
  volume={127 2},
  pages={226-33}
}
Lidocaine and related local anaesthetics have been shown to be effective in the treatment of ulcerative colitis (UC). However, the mechanisms underlying their therapeutic effect are poorly defined. Intestinal epithelial cells play an important role in the mucosal inflammatory response that leads to tissue damage in UC via the secretion of pro-inflammatory cytokines and chemokines. The aim of this study was to evaluate the direct immunoregulatory effect of lidocaine on pro-inflammatory cytokine… CONTINUE READING

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