Lidocaine impairs vasodilation mediated by adenosine triphosphate-sensitive K+ channels but not by inward rectifier K+ channels in rat cerebral microvessels.

@article{Kinoshita2004LidocaineIV,
  title={Lidocaine impairs vasodilation mediated by adenosine triphosphate-sensitive K+ channels but not by inward rectifier K+ channels in rat cerebral microvessels.},
  author={Hiroyuki Kinoshita and Katsutoshi Nakahata and Mayuko Dojo and Yoshiki Kimoto and Yoshio Hatano},
  journal={Anesthesia and analgesia},
  year={2004},
  volume={99 3},
  pages={904-9, table of contents}
}
Vasodilator effects of adenosine triphosphate (ATP)-sensitive, as well as inward rectifier, K+ channel openers have not been well demonstrated in cerebral microvessels. Although lidocaine impairs vasorelaxation via ATP-sensitive K+ channels in the rat aorta, the effects of this compound on K+ channels in the cerebral circulation have not been shown. We designed the present study to examine whether ATP-sensitive and inward rectifier K+ channels contribute to vasodilator responses in cerebral… CONTINUE READING