Lidocaine enhances Galphai protein function.

  title={Lidocaine enhances Galphai protein function.},
  author={Claudia Benkwitz and James C. Garrison and Joel M Linden and Marcel E. Durieux and Markus W Hollmann},
  volume={99 5},
BACKGROUND Local anesthetics inhibit several G protein-coupled receptors by interaction with the Galphaq protein subunit. It is not known whether this effect on G protein function can be extrapolated to other classes of G proteins. The authors investigated interactions of lidocaine with the human adenosine 1 receptor (hA1R)-coupled signaling pathway. Activated A1Rs couple to adenylate cyclase via the pertussis toxin sensitive Galphai protein, thereby decreasing cyclic adenosine monophosphate… CONTINUE READING
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