Lidocaine effects on action potentials of Purkinje fibers from neonatal and adult dogs.

@article{MaryRabine1978LidocaineEO,
  title={Lidocaine effects on action potentials of Purkinje fibers from neonatal and adult dogs.},
  author={Luc Mary-Rabine and Michael R. Rosen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1978},
  volume={205 1},
  pages={
          204-11
        }
}
We studied the effects of lidocaine (L), 2 to 40 mg/l, on the cellular electrophysiologic properties of Purkinje fibers (PF) from neonatal (0-10 days) and adult dogs. Microelectrode impalements of neonatal and adult PF were selected so that there were no differences between the two groups in control maximum diastolic potential, action potential amplitude and maximum upstroke velocity of phase 0 depolarization (Vmax). However, control action potential duration was significantly shorter in… CONTINUE READING