Lidocaine block of human heart sodium channels expressed in Xenopus oocytes.

@article{Chahine1992LidocaineBO,
  title={Lidocaine block of human heart sodium channels expressed in Xenopus oocytes.},
  author={Mohamed Chahine and Li Qian Chen and Robert L. Barchi and Roland G. Kallen and Richard Horn},
  journal={Journal of molecular and cellular cardiology},
  year={1992},
  volume={24 11},
  pages={1231-6}
}
The tertiary amine lidocaine is used clinically for preventing cardiac arrhythmias, and has been widely studied on mammalian tissue. Xenopus oocytes were used as an expression system to study the effect of lidocaine on a sodium (Na) channel, derived from a full-length human heart (hH1) cDNA clone. The concentration dependence of the lidocaine block of hH1 Na current was consistent with a binding stoichiometry of 1:1. At low frequency stimulation, and at holding potentials < or = 100 mV, the… CONTINUE READING

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