Lidocaine and Procaine Alter Rat Brain Amines

@article{Ciarlone1981LidocaineAP,
  title={Lidocaine and Procaine Alter Rat Brain Amines},
  author={Alfred E. Ciarlone and Martin Juras},
  journal={Journal of Dental Research},
  year={1981},
  volume={60},
  pages={1886 - 1890}
}
  • A. Ciarlone, M. Juras
  • Published 1 November 1981
  • Biology, Chemistry, Psychology, Medicine
  • Journal of Dental Research
Lidocaine HCl (100 mg/kg i.p.) or procaine HCl (240 mg/kg i.p.) was injected into rats, which were killed after zero to 12 min. Six brain parts were analyzed for serotonin, norepinephrine, and dopamine. Lidocaine induced depletion of serotonin and of dopamine in some regions and elevation in others; however, it produced elevated levels of norepinephrine. Not all brain regions showed a significant change of amines. Procaine induced elevations of serotonin, norepinephrine, and dopamine… 

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  • A. Ciarlone
  • Biology, Chemistry
    Journal of dental research
  • 1981
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